Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.60 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | CLK1 | P49759 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625104 | 1.00 | DYRK1A (0.60) | DYRK1ADYRK1BMAPTCLK1CYP1A2 | |
| SCHEMBL28587111 | 0.83 | EGFR (0.50) | DYRK1ADYRK1BMAPTNPC1RAB9A | |
| SCHEMBL28587113 | 0.83 | EGFR (0.50) | DYRK1ADYRK1BMAPTNPC1RAB9A | |
| SCHEMBL625784 | 0.80 | KMT2A (0.57) | CYP1A2RAB9AAKR1B1MAOBGAA | |
| SCHEMBL28575415 | 0.79 | ALDH1A1 (0.56) | DYRK1ADYRK1BMAPTCYP1A2PIM1 | |
| SCHEMBL28575414 | 0.79 | ALDH1A1 (0.56) | DYRK1ADYRK1BMAPTCYP1A2PIM1 | |
| SCHEMBL28588030 | 0.78 | KMT2A (0.58) | DYRK1AMAPTCYP1A2RAB9APIM1 | |
| SCHEMBL28915136 | 0.78 | MIF (0.49) | MAPTCYP1A2NPC1RAB9AEGFR | |
| SCHEMBL28915135 | 0.78 | MIF (0.49) | MAPTCYP1A2NPC1RAB9AEGFR | |
| SCHEMBL28588029 | 0.78 | KMT2A (0.58) | DYRK1AMAPTCYP1A2RAB9APIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021692-A1 | CURCUMIN ANALOGS AND METHODS OF USE THEREOF | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2012-02-16 | — | — | WO | disclosed |