Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 5/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | IDH2 | P48735 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625456 | 0.91 | MAP3K12 (0.41) | CCNA2CDK2SYKPIK3CARIPK1 | |
| SCHEMBL625408 | 0.90 | MAP4K1 (0.39) | CCNA2CDK2SYKPIK3CAMAP3K12 | |
| SCHEMBL624428 | 0.89 | MAP3K12 (0.47) | SYKPIK3CAMAP3K12 | |
| SCHEMBL624985 | 0.88 | KDM4E (0.40) | SYKPIK3CAMAP3K12MAP4K1GPR119 | |
| SCHEMBL626892 | 0.88 | PIK3CA (0.42) | PIK3CAMAP3K12MAP4K1 | |
| SCHEMBL625127 | 0.85 | PIK3CA (0.48) | CCNA2CDK2SYKPIK3CARIPK1 | |
| SCHEMBL624922 | 0.85 | PIK3CA (0.42) | PIK3CARIPK1MAP3K12MAP4K1GPR119 | |
| SCHEMBL625861 | 0.85 | GPR119 (0.46) | CCNA2CDK2SYKIDH1IDH2 | |
| SCHEMBL625422 | 0.84 | PIK3CA (0.42) | PIK3CAMAP3K12 | |
| SCHEMBL626207 | 0.84 | MAP3K12 (0.46) | CDK2PIK3CAMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |