SCHEMBL6251412

SCHEMBL6251412

c1ccc(NCCC2CCOCC2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 2/20 0.55
MAOA P21397 2/20 0.55
MAOB P27338 2/20 0.55
KCNH3 Q9ULD8 1/20 0.50
ALDH1A1 P00352 1/20 0.45
MAPT P10636 1/20 0.45
CHRM2 P08172 1/20 0.45
CHRM1 P11229 1/20 0.45
CHRM3 P20309 1/20 0.45
OPRL1 P41146 7/20 0.43
MAN1B1 Q9UKM7 1/20 0.43
NAMPT P43490 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.40
EPHX1 P07099 1/20 0.38
CARM1 Q86X55 1/20 0.38
PRMT6 Q96LA8 1/20 0.38
ICMT O60725 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17064950 0.87 ALDH1A1 (0.54) KDM1AMAOAMAOBALDH1A1MAPT
SCHEMBL6224721 0.83 KDM1A (0.50) KDM1AMAOAMAOBALDH1A1MAPT
SCHEMBL5793778 0.81 KCNH3 (0.65) KDM1AMAOAMAOBKCNH3ALDH1A1
SCHEMBL22694642 0.81 KDM1A (0.53) KDM1AMAOAMAOBALDH1A1MAPT
SCHEMBL21266856 0.81 KDM1A (0.53) KDM1AMAOAMAOBALDH1A1MAPT
SCHEMBL24767234 0.81 KDM1A (0.53) KDM1AMAOAMAOBALDH1A1MAPT
SCHEMBL22404280 0.81 KDM1A (0.53) KDM1AMAOAMAOBALDH1A1MAPT
SCHEMBL15739823 0.79 EGLN2 (0.43) KDM1AMAOAMAOBALDH1A1OPRL1
SCHEMBL27683045 0.79 KDM1A (0.55) KDM1AMAOAMAOBALDH1A1MAPT
SCHEMBL23023116 0.76 SIGMAR1 (0.55) KDM1AMAOAMAOBCHRM2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1562595-A1 DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 2005-08-17 EP disclosed
WO-2004026305-A9 DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONIST LILLY CO ELI (US) 2004-05-13 WO disclosed
WO-2004026305-A1 DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONIST ELI LILLY AND COMPANY (US) 2004-04-01 WO disclosed