SCHEMBL6251430

SCHEMBL6251430

COc1cc2c(c(Cl)c1O)Oc1cc(O)ccc1C21OC(=O)c2cc(Cl)c(C(=O)O)c(OC)c21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FTO Q9C0B1 8/20 0.39
MEN1 O00255 5/20 0.39
KMT2A Q03164 5/20 0.39
MAPT P10636 4/20 0.39
HPGD P15428 3/20 0.39
HTT P42858 2/20 0.39
SMAD3 P84022 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
CYP2C19 P33261 1/20 0.39
RECQL P46063 1/20 0.39
BLM P54132 1/20 0.39
PRMT1 Q99873 1/20 0.39
ACE2 Q9BYF1 1/20 0.39
ALDH1A1 P00352 5/20 0.38
HSD17B10 Q99714 3/20 0.38
ALOX12 P18054 2/20 0.38
CYP2C9 P11712 1/20 0.38
ALOX15 P16050 1/20 0.38
BRCA1 P38398 1/20 0.38
TTR P02766 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29211010 0.81 FTO (0.41) FTOMEN1KMT2AMAPTHPGD
SCHEMBL3418230 0.76 HPGD (0.45) FTOMEN1KMT2AMAPTHPGD
SCHEMBL1682554 0.75 SMAD3 (0.40) MEN1KMT2AMAPTHPGDSMAD3
SCHEMBL93663 0.73 MEN1 (0.31) FTOMEN1KMT2AMAPTHPGD
SCHEMBL3699713 0.73 ALDH1A1 (0.45) FTOMEN1KMT2AMAPTHPGD
SCHEMBL6026564 0.73 SMAD3 (0.41) MEN1KMT2AMAPTHPGDHTT
SCHEMBL29831001 0.73 GNG2 (0.40) FTOMEN1KMT2AMAPTHPGD
SCHEMBL345532 0.73 GNG2 (0.40) FTOMEN1KMT2AMAPTHPGD
SCHEMBL27987131 0.71 FTO (0.59) FTOMEN1KMT2AMAPTHPGD
SCHEMBL29353753 0.71 MEN1 (0.39) MEN1KMT2AMAPTHPGDHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114573692-B Immunoassay and antibodies for detection of chromogranin A 塞尚公司 2024-05-28 CN disclosed
US-20230399455-A1 BIO-FUNCTIONALIZATION OF WATER-SOLUBLE POLY(PHENYLENE EHTYLENE)S UNIV TEXAS (US) 2023-12-14 US disclosed
CN-116819066-A Liver cancer microenvironment detection kit 复旦大学附属中山医院 2023-09-29 CN disclosed
CN-116685329-A Nucleic acid constructs and their use for the treatment of spinal muscular atrophy 杭州嘉因生物科技有限公司 2023-09-01 CN disclosed
CN-116234553-A Methods of treating systemic lupus erythematosus and use of biomarkers as predictors of clinical sensitivity to therapy 新基公司 2023-06-06 CN disclosed
CN-116157666-A Electric field assisted sample preparation 安捷伦科技有限公司 2023-05-23 CN disclosed
CN-116096884-A Isothermal methods, compositions, kits and systems for detecting nucleic acids 哈佛大学校长及研究员协会 2023-05-09 CN disclosed
CN-115280148-A Method for determining peptidylglycine alpha-amidating monooxygenase (PAM) and use thereof for diagnostic purposes PAM治疗诊断有限公司 2022-11-01 CN disclosed
CN-115243709-A Use of peptidylglycine alpha-amidating monooxygenase (PAM) for therapeutic purposes PAM治疗诊断有限公司 2022-10-25 CN disclosed
CN-115003827-A Analyte detection 密歇根大学董事会 2022-09-02 CN disclosed
CN-114196746-A Detection of nucleic acids 密歇根大学董事会 2022-03-18 CN disclosed
CN-105917232-B Method for selective determination of placental growth factor 2 塞尚公司 2020-10-16 CN disclosed
CN-111542755-A Selenoprotein P for prediction of first cardiovascular events 思芬构技术有限公司 2020-08-14 CN disclosed
CN-111295588-A Method for determining the selectivity of a test compound 分子医学研究中心责任有限公司 2020-06-16 CN disclosed
CN-110730826-A Analyte detection 密歇根大学董事会 2020-01-24 CN disclosed
WO-2005049849-A2 FLUORESCENCE QUENCHING AZO DYES, THEIR METHODS OF PREPARATION AND USE INTEGRATED DNA TECHNOLOGIES, INC. (US) 2005-06-02 WO disclosed
WO-2002061130-A2 METHODS AND REAGENTS FOR ANALYSIS OF RNA STRUCTURE AND FUNCTION TRANSGENOMIC, INC. (US) 2002-08-08 WO disclosed
WO-1998014612-A9 CYANINE DYES WITH HIGH-ABSORBANCE CROSS SECTION AS DONOR CHROMOPHORES IN ENERGY TRANSFER LABELS 1998-07-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230399455-A1 BIO-FUNCTIONALIZATION OF WATER-SOLUBLE POLY(PHENYLENE EHTYLENE)S PGLS, EPCAM, CD69 FTO 867/4885MEN1 3472/4885KMT2A 1951/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.