Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.39 |
| ▸ | NQO2 | P16083 | 4/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | PPM1G | O15355 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | PPM1A | P35813 | 1/20 | 0.36 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946276 | 0.83 | ACHE (0.40) | NQO2PTGESPPM1GALOX5PTPN1 | |
| SCHEMBL1617314 | 0.82 | MAPK14 (0.40) | PTGESPPM1GALOX5PTPN1KDM5A | |
| SCHEMBL29617385 | 0.82 | MAPK14 (0.40) | PTGESPPM1GALOX5PTPN1KDM5A | |
| SCHEMBL8436758 | 0.82 | KMT2A (0.42) | MEN1ALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL19152266 | 0.81 | GABRA2 (0.42) | NQO2MEN1NPC1ALDH1A1CYP1A2 | |
| SCHEMBL13947511 | 0.80 | GRIK1 (0.37) | PTGESPPM1GALOX5PTPN1KDM5A | |
| SCHEMBL17372704 | 0.80 | MAPT (0.37) | PTGESPPM1GALOX5PTPN1KDM5A | |
| SCHEMBL1613356 | 0.80 | PTGES (0.38) | PTGESPPM1GALOX5PTPN1KDM5A | |
| SCHEMBL9391555 | 0.78 | NQO2 (0.40) | GRM2NQO2PTGESPPM1GALOX5 | |
| SCHEMBL17372709 | 0.77 | MAPT (0.45) | NPC1ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6962930-B1 | Compounds, compositions and method suitable for amelioration of withdrawal syndromes and withdrawal-induced brain damage | LOHOCLA RESEARCH CORPORATION (US) | 2005-11-08 | — | — | US | disclosed |
| EP-1011676-B1 | QUINOLINE-UREA DERIVATIVES FOR THE TREATMENT OF WITHDRAWAL SYNDROME AND WITHDRAWAL-INDUCED BRAIN DAMAGE | LOHOCLA RES CORP (US) | 2005-08-31 | — | — | EP | disclosed |
| EP-1011676-A4 | COMPOUNDS, COMPOSITIONS AND METHOD SUITABLE FOR AMELIORATION OF WITHDRAWAL SYNDROMES AND WITHDRAWAL-INDUCED BRAIN DAMAGE | LOHOCLA RES CORP (US) | 2004-08-11 | — | — | EP | disclosed |
| EP-1011676-A1 | COMPOUNDS, COMPOSITIONS AND METHOD SUITABLE FOR AMELIORATION OF WITHDRAWAL SYNDROMES AND WITHDRAWAL-INDUCED BRAIN DAMAGE | Lohocla Research Corporation (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-1998055125-A1 | COMPOUNDS, COMPOSITIONS AND METHOD SUITABLE FOR AMELIORATION OF WITHDRAWAL SYNDROMES AND WITHDRAWAL-INDUCED BRAIN DAMAGE | LOHOCLA RESEARCH CORPORATION (US) | 1998-12-10 | — | — | WO | disclosed |