Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 7/20 | 0.64 |
| ▸ | METAP2 | P50579 | 5/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiabendazole SCHEMBL724613 | 0.89 | METAP1 (0.77) | METAP1METAP2HDAC6NPC1RAB9A | |
| Thiabendazole SCHEMBL11570001 | 0.84 | METAP1 (0.77) | METAP1METAP2HDAC6NPC1RAB9A | |
| Thiabendazole SCHEMBL28860081 | 0.81 | METAP1 (0.81) | METAP1METAP2HDAC6NPC1RAB9A | |
| Thiabendazole SCHEMBL625588 | 0.80 | METAP1 (1.00) | METAP1METAP2HDAC6NPC1RAB9A | |
| Thiabendazole SCHEMBL29370729 | 0.80 | METAP1 (1.00) | METAP1METAP2HDAC6NPC1RAB9A | |
| Thiabendazole SCHEMBL19842 | 0.80 | METAP1 (1.00) | METAP1METAP2HDAC6NPC1RAB9A | |
| Thiabendazole SCHEMBL9118431 | 0.79 | METAP1 (0.56) | METAP1METAP2HDAC6NPC1RAB9A | |
| Thiabendazole SCHEMBL10750369 | 0.79 | METAP1 (0.68) | METAP1METAP2HDAC6NPC1RAB9A | |
| Thiabendazole SCHEMBL11218788 | 0.79 | METAP1 (0.97) | METAP1METAP2HDAC6NPC1RAB9A | |
| Thiabendazole SCHEMBL7733801 | 0.79 | METAP1 (0.97) | METAP1METAP2HDAC6NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2637501-A2 | FUNGICIDAL COMPOSITIONS AND METHODS OF USE | The Board Of Trustees Of The University Of Alabama (US) | 2013-09-18 | — | — | EP | disclosed |
| US-20130217735-A1 | FUNGICIDAL COMPOSITIONS AND METHODS OF USE | AGRI-FOOD AND BIOSCIENCES INSTITUTE (GB) | 2013-08-22 | — | — | US | disclosed |
| WO-2012021825-A2 | FUNGICIDAL COMPOSITIONS AND METHODS OF USE | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217735-A1 | FUNGICIDAL COMPOSITIONS AND METHODS OF USE | PIK3C3, CYP4X1, CYP51A1 | METAP1 2020/4885METAP2 1304/4885HDAC6 1404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.