Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Thiabendazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 8/20 | 0.77 |
| ▸ | METAP2 | P50579 | 6/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.77 |
| ▸ | NPC1 | O15118 | 1/20 | 0.77 |
| ▸ | TP53 | P04637 | 1/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.77 |
| ▸ | RAB9A | P51151 | 1/20 | 0.77 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.77 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.77 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiabendazole SCHEMBL11570001 | 0.92 | METAP1 (0.77) | METAP1METAP2KDM4ENPC1TP53 | |
| Thiabendazole SCHEMBL28860081 | 0.90 | METAP1 (0.81) | METAP1METAP2KDM4ENPC1TP53 | |
| Stearic Acid SCHEMBL625230 | 0.89 | METAP1 (0.64) | METAP1METAP2KDM4ENPC1TP53 | |
| Thiabendazole SCHEMBL29370729 | 0.88 | METAP1 (1.00) | METAP1METAP2KDM4ENPC1TP53 | |
| Thiabendazole SCHEMBL19842 | 0.88 | METAP1 (1.00) | METAP1METAP2KDM4ENPC1TP53 | |
| Thiabendazole SCHEMBL625588 | 0.88 | METAP1 (1.00) | METAP1METAP2KDM4ENPC1TP53 | |
| Thiabendazole SCHEMBL7733801 | 0.86 | METAP1 (0.97) | METAP1METAP2KDM4ENPC1TP53 | |
| Thiabendazole SCHEMBL2314460 | 0.86 | METAP1 (0.97) | METAP1METAP2KDM4ENPC1TP53 | |
| Thiabendazole SCHEMBL28861440 | 0.86 | METAP1 (0.97) | METAP1METAP2KDM4ENPC1TP53 | |
| Thiabendazole SCHEMBL9856779 | 0.86 | METAP1 (0.97) | METAP1METAP2KDM4ENPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9155735-B2 | Medical device coatings | TYRX, INC. (US) | 2015-10-13 | — | — | US | disclosed |
| US-20120052292-A1 | NOVEL MEDICAL DEVICE COATINGS | TYRX PHARMA, INC. (US) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120052292-A1 | NOVEL MEDICAL DEVICE COATINGS | TLR5, TLR4, TLR3 | METAP1 2449/4885METAP2 2088/4885KDM4E 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.