Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 11/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.45 |
| ▸ | GAK | O14976 | 1/20 | 0.45 |
| ▸ | STK10 | O94804 | 1/20 | 0.45 |
| ▸ | YES1 | P07947 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.45 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.45 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.45 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.45 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.45 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624449 | 0.94 | PIM1 (0.69) | PIM1KCNH2DYRK1APIM2 | |
| SCHEMBL624481 | 0.86 | PIM1 (0.56) | PIM1KCNH2DYRK1APIM2GAK | |
| SCHEMBL625254 | 0.84 | PIM3 (0.51) | PIM1KCNH2DYRK1APIM3HASPIN | |
| SCHEMBL625776 | 0.83 | PIM1 (0.55) | PIM1KCNH2DYRK1APIM2GAK | |
| SCHEMBL623866 | 0.82 | DYRK1A (0.48) | PIM1KCNH2DYRK1A | |
| SCHEMBL623998 | 0.79 | PIM1 (0.51) | PIM1KCNH2DYRK1APIM2GAK | |
| SCHEMBL624739 | 0.79 | PIM1 (0.47) | PIM1KCNH2DYRK1AHASPIN | |
| SCHEMBL623948 | 0.79 | DYRK1A (0.47) | PIM1KCNH2DYRK1APIM3HASPIN | |
| SCHEMBL624016 | 0.78 | PIM1 (0.49) | PIM1KCNH2PIM2GAKSTK10 | |
| SCHEMBL623868 | 0.78 | DYRK1A (0.44) | PIM1KCNH2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |