Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | CCR2 | P41597 | 2/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17761304 | 0.87 | SLC6A4 (0.62) | SLC6A4SLC6A3SLC6A2CCR2EPHX2 | |
| SCHEMBL5079244 | 0.83 | SLC6A4 (0.52) | SLC6A4SLC6A3SLC6A2CCR2EPHX2 | |
| SCHEMBL14893184 | 0.82 | SLC6A4 (0.66) | SLC6A4SLC6A3SLC6A2CCR2EPHX2 | |
| SCHEMBL625060 | 0.82 | HSD11B1 (0.62) | SLC6A4SLC6A3SLC6A2EPHX2HSD11B1 | |
| SCHEMBL17761230 | 0.81 | SLC6A4 (0.57) | SLC6A4SLC6A3SLC6A2CCR2HSD11B1 | |
| SCHEMBL627858 | 0.81 | HSD11B1 (0.60) | SLC6A4SLC6A3SLC6A2CCR2HSD11B1 | |
| SCHEMBL624806 | 0.80 | SLC6A4 (0.56) | SLC6A4SLC6A3SLC6A2CCR2EPHX2 | |
| SCHEMBL624122 | 0.80 | HSD11B1 (0.46) | HSD11B1 | |
| SCHEMBL28886303 | 0.79 | TACR1 (0.50) | SLC6A4SLC6A3SLC6A2CCR2OPRM1 | |
| SCHEMBL625891 | 0.79 | SLC6A4 (0.49) | SLC6A4SLC6A3SLC6A2CCR2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9156788-B2 | TRPV3 modulators | ABBVIE INC. (US) | 2015-10-13 | — | — | US | disclosed |
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| US-20130150409-A1 | NOVEL TRPV3 MODULATORS | ABBVIE INC. (US) | 2013-06-13 | — | — | US | disclosed |
| CN-103140476-A | Novel trpv3 modulators | ABBOTT LAB | 2013-06-05 | — | — | CN | disclosed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150409-A1 | NOVEL TRPV3 MODULATORS | TRPV3, TRPV4, TRPV5 | SLC6A4 511/4885SLC6A3 717/4885SLC6A2 1774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.