Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 1.00 |
| ▸ | BCR | P11274 | 13/20 | 1.00 |
| ▸ | PRKCA | P17252 | 8/20 | 1.00 |
| ▸ | PRKCD | Q05655 | 6/20 | 1.00 |
| ▸ | SRC | P12931 | 8/20 | 0.73 |
| ▸ | EGFR | P00533 | 3/20 | 0.73 |
| ▸ | PRKACA | P17612 | 1/20 | 0.73 |
| ▸ | PRKACG | P22612 | 1/20 | 0.73 |
| ▸ | PRKACB | P22694 | 1/20 | 0.73 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.71 |
| ▸ | PLK1 | P53350 | 1/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.63 |
| ▸ | PRKCG | P05129 | 1/20 | 0.63 |
| ▸ | PRKCB | P05771 | 1/20 | 0.63 |
| ▸ | PRKCH | P24723 | 1/20 | 0.63 |
| ▸ | PRKCI | P41743 | 1/20 | 0.63 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.63 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4899574 | 0.86 | ABL1 (0.76) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL3510842 | 0.86 | ABL1 (0.75) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL29618427 | 0.84 | ABL1 (0.85) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL7476769 | 0.84 | ABL1 (1.00) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL7461678 | 0.84 | ABL1 (0.73) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL1465 | 0.84 | ABL1 (1.00) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL4084867 | 0.84 | ABL1 (0.77) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL6262145 | 0.83 | ABL1 (1.00) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL12801709 | 0.83 | CAMK2D (1.00) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL12275705 | 0.83 | CAMK2D (0.73) | ABL1BCRPRKCAPRKCDCAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005065074-A2 | PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2005-07-21 | — | — | WO | claimed |
| US-5516775-A | TO INHIBIT PROTEIN KINASE C | CIBA-GEIGY CORPORATION (US) | 1996-05-14 | — | — | US | claimed |
| EP-0588762-A1 | Use of pyrimidine derivatives as inhibitors of proteinkinase C and antitumor drugs | CIBA-GEIGY AG (CH) | 1994-03-23 | — | — | EP | claimed |
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| US-5516775-A | TO INHIBIT PROTEIN KINASE C | CIBA-GEIGY CORPORATION (US) | 1996-05-14 | — | — | US | disclosed |
| EP-0588762-A1 | Use of pyrimidine derivatives as inhibitors of proteinkinase C and antitumor drugs | CIBA-GEIGY AG (CH) | 1994-03-23 | — | — | EP | disclosed |