SCHEMBL6254908

SCHEMBL6254908

CC(C)(C)[Si]1(c2ccccc2)C(c2ccc(-c3ccccc3)nc2)=C(c2ccccc2)C(c2ccccc2)=C1c1ccc(-c2ccccc2)nc1

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HPGDS O60760 2/20 0.39
LDHA P00338 1/20 0.36
BAZ2B Q9UIF8 1/20 0.35
DGAT1 O75907 1/20 0.34
CYP11B1 P15538 5/20 0.33
CYP11B2 P19099 5/20 0.33
CHRNB2 P17787 3/20 0.33
CHRNA3 P32297 2/20 0.33
CHRNA7 P36544 2/20 0.33
CHRNA4 P43681 2/20 0.33
CYP3A4 P08684 1/20 0.33
HSD17B1 P14061 1/20 0.33
HSD17B2 P37059 1/20 0.33
CHRNB4 P30926 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6255975 0.89 CYP1A1 (0.38) CYP11B1CYP11B2HSD17B1HSD17B2
SCHEMBL6257861 0.86 NPC1 (0.35) HPGDS
SCHEMBL6255405 0.84 PTGS2 (0.30)
SCHEMBL6257000 0.84 CYP11B1 (0.36) CYP11B1CYP11B2
SCHEMBL6259252 0.83 PTGS2 (0.31)
SCHEMBL6255419 0.81 PDE4B (0.31)
SCHEMBL6257790 0.80 HPGDS (0.44) HPGDSLDHABAZ2BCYP11B1CYP11B2
SCHEMBL6257555 0.80
SCHEMBL8335527 0.79 KIF11 (0.41) CYP11B1CYP11B2CYP3A4
SCHEMBL6254179 0.79 HPGDS (0.45) HPGDSLDHABAZ2BCYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed