Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | DAO | P14920 | 1/20 | 0.61 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.61 |
| ▸ | CES2 | O00748 | 6/20 | 0.59 |
| ▸ | CES1 | P23141 | 6/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL6130390 | 1.00 | TSHR (0.61) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL28364663 | 0.98 | TSHR (0.58) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL20985706 | 0.96 | DAO (0.56) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL8436626 | 0.92 | NAPRT (0.52) | TSHRDAONAPRTCES2CES1 | |
| Terephthalic Acid SCHEMBL9943962 | 0.91 | FFAR3 (0.62) | TSHRHDAC3HDAC1HDAC2HDAC8 | |
| Benzoic Acid SCHEMBL5787758 | 0.88 | CES2 (0.61) | TSHRDAONAPRTCES2CES1 | |
| Benzophenone SCHEMBL27608423 | 0.87 | ALDH1A1 (0.61) | CES2CES1HDAC3HDAC1HDAC2 | |
| Benzoic Acid SCHEMBL2762272 | 0.86 | TSHR (0.74) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL578126 | 0.86 | TSHR (0.74) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL29286711 | 0.86 | TSHR (0.74) | TSHRDAONAPRTCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834516-B2 | Regioselectively substituted cellulose esters produced in a carboxylated ionic liquid process and products produced therefrom | EASTMAN CHEMICAL COMPANY (US) | 2017-12-05 | — | — | US | claimed |
| CN-103360241-A | Method for preparing optically pure 5-oxo-tricyclo [2,2,1,02,6] heptane-3-carboxylic acid | UNIV CHINA PHARMA | 2013-10-23 | — | — | CN | claimed |
| CN-103288699-A | Preparation method of proline analogue | UNIV CHINA PHARMA | 2013-09-11 | — | — | CN | claimed |
| US-20130190485-A1 | REGIOSELECTIVELY SUBSTITUTED CELLULOSE ESTERS PRODUCED IN A HALOGENATED IONIC LIQUID PROCESS AND PRODUCTS PRODUCED THEREFROM | EASTMAN CHEMICAL COMPANY (US) | 2013-07-25 | — | — | US | claimed |
| US-8354525-B2 | Regioselectively substituted cellulose esters produced in a halogenated ionic liquid process and products produced therefrom | EASTMAN CHEMICAL COMPANY (US) | 2013-01-15 | — | — | US | claimed |
| US-20110213138-A1 | REGIOSELECTIVELY SUBSTITUTED CELLULOSE ESTERS PRODUCED IN A HALOGENATED IONIC LIQUID PROCESS AND PRODUCTS PRODUCED THEREFROM | EASTMAN CHEMICAL COMPANY (US) | 2011-09-01 | — | — | US | claimed |
| US-20100029927-A1 | Use of ionic liquid with carboxylate anion and acylating agent; use as films such as photographic film, protective film, or compensation films for liquid crystalline displays | EASTMAN CHEMICAL COMPANY (US) | 2010-02-04 | — | — | US | claimed |
| CN-101525322-A | New technology for synthesizing Corey lactonic acid by pan boiling method | UNIV CHINA PHARMA | 2009-09-09 | — | — | CN | claimed |
| EP-0170500-B1 | NOVEL 9 ALPHA-FLUORO- OR CHLORO-CORTICOSTEROID ESTERS AND A PROCESS FOR THEIR PREPARATION | HOVIONE INTER LTD. (CH) | 1990-10-10 | — | — | EP | claimed |
| US-11988960-B2 | Organometallic solution based high resolution patterning compositions | INPRIA CORPORATION (US) | 2024-05-21 | — | — | US | disclosed |
| US-11988958-B2 | Organometallic solution based high resolution patterning compositions | INPRIA CORPORATION (US) | 2024-05-21 | — | — | US | disclosed |
| US-11966159-B2 | Organometallic solution based high resolution patterning compositions | INPRIA CORPORATION (US) | 2024-04-23 | — | — | US | disclosed |
| CN-117794524-A | Local anesthetic-clay composite composition | 竟天生物科技股份有限公司 | 2024-03-29 | — | — | CN | disclosed |
| US-20230377890-A1 | SELECTIVE DEPOSITION OF CARBON ON PHOTORESIST LAYER FOR LITHOGRAPHY APPLICATIONS | APPLIED MATERIALS, INC. | 2023-11-23 | — | — | US | disclosed |
| CN-1242013-A | Acid addition salts of optically active piperidine compounds and process for preparing the same | UBE INDUSTRIES (JP) | 2000-01-19 | — | — | CN | disclosed |
| US-5026693-A | Novel 9α-fluoro- or chloro-corticosteroid esters and a process for their preparation | HOVIONE INTER LTD. (CH) | 1991-06-25 | — | — | US | disclosed |
| EP-0170500-B1 | NOVEL 9 ALPHA-FLUORO- OR CHLORO-CORTICOSTEROID ESTERS AND A PROCESS FOR THEIR PREPARATION | HOVIONE INTER LTD. (CH) | 1990-10-10 | — | — | EP | disclosed |
| CN-1006070-B | Process for the preparation of novel 9 alpha-fluoro and chlorinated corticosteroid lipids | 霍维奥尼·英特有限公司 | 1989-12-13 | — | — | CN | disclosed |
| EP-0170500-A2 | Novel 9 alpha-fluoro- or chloro-corticosteroid esters and a process for their preparation | HOVIONE INTER LTD. (CH) | 1986-02-05 | — | — | EP | disclosed |
| US-4124707-A | 7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor | SCHERING CORPORATION (US) | 1978-11-07 | — | — | US | disclosed |