Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.54 |
| ▸ | CTSL | P07711 | 2/20 | 0.54 |
| ▸ | CTSS | P25774 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 1/20 | 0.54 |
| ▸ | CCKBR | P32239 | 7/20 | 0.53 |
| ▸ | REN | P00797 | 2/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4842426 | 0.94 | TACR1 (0.55) | TACR1CTSLCTSSCTSKCCKBR | |
| SCHEMBL17534565 | 0.84 | TACR1 (0.67) | TACR1CTSLCTSSCTSKCCKBR | |
| SCHEMBL17534559 | 0.84 | TACR1 (0.67) | TACR1CTSLCTSSCTSKCCKBR | |
| SCHEMBL6430686 | 0.84 | TACR1 (0.56) | TACR1CTSLCTSSCTSKTP53 | |
| SCHEMBL31289555 | 0.83 | CTSL (0.70) | TACR1CTSLCTSSCTSKCCKBR | |
| SCHEMBL4068546 | 0.83 | CTSL (0.56) | TACR1CTSLCTSSCTSKCCKBR | |
| SCHEMBL4061921 | 0.82 | NMBR (0.66) | TACR1CTSLCTSSCTSKCCKBR | |
| SCHEMBL6255370 | 0.81 | TACR1 (0.54) | TACR1CTSLCTSSCTSKCCKBR | |
| SCHEMBL7433228 | 0.81 | PKM (0.56) | TACR1CTSLCTSSCTSKMMP2 | |
| SCHEMBL7433229 | 0.81 | PKM (0.56) | TACR1CTSLCTSSCTSKMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572645-A2 | DERIVATIVES OF SUCCINIC AND GLUTARIC ACIDS AND ANALOGS THEREOF USEFUL AS INHIBITORS OF PHEX | Enobia Pharma Inc. (CA) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004050620-A2 | DERIVATIVES OF SUCCINIC AND GLUTARIC ACIDS AND ANALOGS THEREOF USEFUL AS INHIBITORS OF PHEX | ENOBIA PHARMA (CA) | 2004-06-17 | — | — | WO | disclosed |