SCHEMBL6255403

SCHEMBL6255403

C=CCON=Cc1ccc(-c2ccccc2NC(=O)Oc2sc(C)nc2C(F)F)cc1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC2 Q92769 1/20 0.33
NFKB1 P19838 1/20 0.32
RAB9A P51151 1/20 0.32
NFKB2 Q00653 1/20 0.32
RELA Q04206 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
KDM4E B2RXH2 1/20 0.31
CHRM3 P20309 5/20 0.31
ALDH1A1 P00352 1/20 0.30
MEN1 O00255 1/20 0.30
LMNA P02545 1/20 0.30
HPGD P15428 1/20 0.30
KMT2A Q03164 1/20 0.30
CHRM2 P08172 1/20 0.30
CHRM1 P11229 1/20 0.30
TRPV1 Q8NER1 1/20 0.30
NPY1R P25929 1/20 0.30
NPY2R P49146 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3030942 0.87 MAPT (0.35) MAPTHDAC1HDAC2RAB9ASMN1; SMN2
SCHEMBL13215931 0.87 MAPT (0.35) MAPTHDAC1HDAC2RAB9ASMN1; SMN2
SCHEMBL3030947 0.87 MAPT (0.35) MAPTHDAC1HDAC2RAB9ASMN1; SMN2
SCHEMBL1019446 0.80 POLB (0.38) MAPTCHRM3ALDH1A1MEN1LMNA
SCHEMBL1018834 0.79 CHRM3 (0.44) MAPTRAB9ACHRM3ALDH1A1MEN1
SCHEMBL4733778 0.78 ALDH1A1 (0.38) RAB9ASMN1; SMN2KDM4EALDH1A1MEN1
SCHEMBL13215927 0.77 HTT (0.40) MAPTSMN1; SMN2KDM4EALDH1A1MEN1
SCHEMBL4733467 0.77 CA2 (0.44) MAPTKDM4EMEN1KMT2A
SCHEMBL4790543 0.76 IRAK4 (0.37) MAPTKDM4EALDH1A1LMNA
SCHEMBL4790540 0.76 IRAK4 (0.37) MAPTKDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1572663-B1 BIPHENYLCARBOXAMIDES BAYER CROPSCIENCE AG (DE) 2013-03-20 EP disclosed
EP-1572663-A1 BIPHENYLCARBOXAMIDES Bayer CropScience AG (DE) 2005-09-14 EP disclosed
WO-2004054982-A1 BIPHENYLCARBOXAMIDES BAYER CROPSCIENCE AG (DE) 2004-07-01 WO disclosed