SCHEMBL6255883

SCHEMBL6255883

CC[Si]1(CC)C(c2ccc(C(F)(F)F)cc2)=C(c2ccccc2)C(c2ccccc2)=C1c1ccc(C(F)(F)F)cc1

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 6/20 0.53
BACE1 P56817 2/20 0.42
SCN2A Q99250 2/20 0.41
ALDH1A1 P00352 1/20 0.41
TSHR P16473 1/20 0.41
DPP4 P27487 1/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
PTGS1 P23219 1/20 0.36
PTGS2 P35354 1/20 0.36
GLO1 Q04760 1/20 0.35
RORC P51449 1/20 0.35
TRPV6 Q9H1D0 1/20 0.35
AGXT P21549 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10018831 0.94 KIF11 (0.47) KIF11BACE1SCN2AALDH1A1TSHR
SCHEMBL6258000 0.86 KIF11 (0.52) KIF11BACE1SCN2AALDH1A1TSHR
SCHEMBL6259136 0.84 SCN2A (0.43) KIF11SCN2AALDH1A1TSHRMEN1
SCHEMBL10018833 0.84 SMN1; SMN2 (0.38) ALDH1A1
SCHEMBL6253373 0.84 ALDH1A1 (0.35) ALDH1A1KMT2A
SCHEMBL6256567 0.81 PTGS1 (0.40) ALDH1A1TSHRDPP4MEN1KMT2A
SCHEMBL7120750 0.81 KIF11 (0.59) KIF11BACE1SCN2AALDH1A1TSHR
SCHEMBL6253074 0.81 KIF11 (0.53) KIF11BACE1SCN2AALDH1A1TSHR
SCHEMBL6256991 0.80 RAB9A (0.39) ALDH1A1TSHRDPP4MEN1KMT2A
SCHEMBL6255652 0.78 NOTUM (0.48) ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed