SCHEMBL6255891

SCHEMBL6255891

CCc1cccc(C2=C(c3cccc(CC)c3)[Si](CC)(CC)C(c3cccc(CC)c3)=C2c2cccc(CC)c2)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 1/20 0.42
IDO1 P14902 1/20 0.41
NISCH Q9Y2I1 1/20 0.41
NOTUM Q6P988 1/20 0.39
PTGS2 P35354 1/20 0.39
TP53 P04637 1/20 0.35
CTSS P25774 1/20 0.35
CTSK P43235 1/20 0.35
MGLL Q99685 1/20 0.34
CHRM3 P20309 2/20 0.34
FGFR1 P11362 1/20 0.34
CHRM2 P08172 1/20 0.34
CHRM4 P08173 1/20 0.34
CHRM5 P08912 1/20 0.34
CHRM1 P11229 1/20 0.34
MME P08473 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2A6 P11509 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6257760 0.84 BCL2 (0.41) BCL2IDO1NISCHNOTUMPTGS2
SCHEMBL6252076 0.84 BCL2 (0.44) BCL2IDO1NISCHNOTUMPTGS2
SCHEMBL6254056 0.80 ACHE (0.39) IDO1NISCHCTSSCTSKALDH1A1
SCHEMBL6255625 0.78 BCL2 (0.43) BCL2IDO1NISCHNOTUMPTGS2
SCHEMBL6253418 0.77 BCL2 (0.39) BCL2IDO1NISCHNOTUMPTGS2
SCHEMBL6256580 0.76 KIF11 (0.45) CTSSCTSKSIGMAR1
SCHEMBL29489424 0.76 BCL2 (0.62) BCL2IDO1NISCHNOTUMPTGS2
SCHEMBL5547358 0.76 BCL2 (0.62) BCL2IDO1NISCHNOTUMPTGS2
SCHEMBL6254883 0.74 RAB9A (0.41) TP53ALDH1A1SMN1; SMN2
SCHEMBL6257477 0.73 BCL2 (0.39) BCL2IDO1NISCHNOTUMPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed