Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6258095 | 0.91 | AURKA (0.49) | PIK3CDRXFP1KDM4ETHRBLMNA | |
| SCHEMBL6254976 | 0.86 | KDM4E (0.41) | KDM4EALDH1A1HPGDHTTLMNA | |
| SCHEMBL6256484 | 0.82 | KDM4E (0.43) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL6259201 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL6257629 | 0.81 | POLB (0.56) | KDM4EALDH1A1MEN1MAPTHPGD | |
| SCHEMBL6254981 | 0.80 | KDM4E (0.48) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL6260924 | 0.75 | MEN1 (0.43) | RXFP1KDM4EALDH1A1MEN1HPGD | |
| SCHEMBL6256148 | 0.73 | MEN1 (0.43) | RXFP1KDM4EALDH1A1MEN1MAPT | |
| SCHEMBL6260233 | 0.72 | GRM2 (0.47) | RXFP1KDM4EALDH1A1MEN1MAPT | |
| SCHEMBL7730189 | 0.71 | MEN1 (0.44) | PIK3CDRXFP1KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1156039-B1 | PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME | KOWA CO (JP) | 2005-10-05 | — | — | EP | disclosed |
| US-6680316-B1 | INTERLEUKIN INHIBITORS; AUTOIMMUNE, RHEUMATIC, AND GASTROINTESTINAL DISORDERS; OSTEOPOROSIS; ANTIINFLAMMATORY, ANTIISCHEMIC, AND ANTIARTHRITIC AGENTS | KOWA CO., LTD. (JP) | 2004-01-20 | — | — | US | disclosed |
| EP-1156039-A1 | PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2001-11-21 | — | — | EP | disclosed |