Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6258728 | 0.91 | PIK3CD (0.44) | AURKATP53THRBRXFP1KDM4E | |
| SCHEMBL6254976 | 0.87 | KDM4E (0.41) | TP53KDM4ELMNASMN1; SMN2 | |
| SCHEMBL6256484 | 0.85 | KDM4E (0.43) | TP53KDM4ELMNASMN1; SMN2 | |
| SCHEMBL6259201 | 0.82 | KDM4E (0.43) | TP53KDM4ELMNASMN1; SMN2 | |
| SCHEMBL6257629 | 0.82 | POLB (0.56) | TP53THRBKDM4ESMN1; SMN2 | |
| SCHEMBL6254981 | 0.81 | KDM4E (0.48) | TP53KDM4ELMNASMN1; SMN2 | |
| SCHEMBL6256619 | 0.77 | CYP1A2 (0.48) | TP53KDM4ELMNASMN1; SMN2 | |
| SCHEMBL6259734 | 0.76 | CYP1A2 (0.47) | TP53KDM4ELMNASMN1; SMN2 | |
| SCHEMBL6260924 | 0.76 | MEN1 (0.43) | THRBRXFP1KDM4ESMN1; SMN2 | |
| SCHEMBL6258294 | 0.74 | EDNRB (0.53) | TP53KDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1156039-B1 | PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME | KOWA CO (JP) | 2005-10-05 | — | — | EP | disclosed |
| US-6680316-B1 | INTERLEUKIN INHIBITORS; AUTOIMMUNE, RHEUMATIC, AND GASTROINTESTINAL DISORDERS; OSTEOPOROSIS; ANTIINFLAMMATORY, ANTIISCHEMIC, AND ANTIARTHRITIC AGENTS | KOWA CO., LTD. (JP) | 2004-01-20 | — | — | US | disclosed |
| EP-1156039-A1 | PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2001-11-21 | — | — | EP | disclosed |