Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 7/20 | 0.49 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627782 | 0.88 | PIK3CA (0.56) | PIK3CAMKNK1FYN | |
| SCHEMBL626701 | 0.88 | MKNK1 (0.52) | PIK3CAMKNK1FYN | |
| SCHEMBL627610 | 0.88 | FYN (0.56) | PIK3CAMKNK1FYN | |
| SCHEMBL627612 | 0.88 | FYN (0.56) | PIK3CAMKNK1FYN | |
| SCHEMBL626581 | 0.87 | FYN (0.47) | PIK3CAMKNK1FYN | |
| SCHEMBL624984 | 0.86 | PIK3CA (0.48) | PIK3CAMKNK1FYN | |
| SCHEMBL625673 | 0.84 | MAP3K12 (0.48) | PIK3CAMAP3K12 | |
| SCHEMBL626268 | 0.80 | PIK3CA (0.59) | PIK3CAMKNK1FYN | |
| SCHEMBL626288 | 0.78 | PIK3CA (0.51) | PIK3CAFYN | |
| SCHEMBL626144 | 0.78 | PIK3CA (0.57) | PIK3CAMKNK1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |