Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.71 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.71 |
| ▸ | PGK1 | P00558 | 4/20 | 0.66 |
| ▸ | PGK2 | P07205 | 4/20 | 0.66 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5388703 | 0.92 | ADORA2B (0.60) | ADORA2AADORA2BPGK1PGK2SLC29A1 | |
| SCHEMBL5389218 | 0.92 | ADORA2A (0.74) | ADORA2AADORA2BPGK1PGK2ADORA3 | |
| SCHEMBL7083928 | 0.92 | ADORA2A (0.74) | ADORA2AADORA2BPGK1PGK2ADORA3 | |
| SCHEMBL4806899 | 0.88 | PGK1 (0.85) | ADORA2BPGK1PGK2SLC29A1ADORA3 | |
| SCHEMBL5393072 | 0.88 | ADORA3 (0.77) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL5389657 | 0.88 | ADORA3 (0.77) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL6262523 | 0.86 | ADORA1 (0.71) | ADORA2AADORA2BPGK1PGK2ADORA3 | |
| SCHEMBL5386790 | 0.86 | ADORA1 (0.71) | ADORA2AADORA2BPGK1PGK2ADORA3 | |
| SCHEMBL6262513 | 0.86 | ADORA1 (0.71) | ADORA2AADORA2BPGK1PGK2ADORA3 | |
| SCHEMBL6262904 | 0.85 | ADORA2A (0.70) | ADORA2AADORA2BPGK1PGK2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414837-B1 | ADENOSINE A3 RECEPTOR AGONISTS | CV THERAPEUTICS INC (US) | 2005-10-19 | — | — | EP | disclosed |
| EP-1414837-A1 | ADENOSINE A3 RECEPTOR AGONISTS | CV THERAPEUTICS, INC. (US) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003014137-A1 | ADENOSINE A3 RECEPTOR AGONISTS | CV THERAPEUTICS, INC. (US) | 2003-02-20 | — | — | WO | disclosed |