SCHEMBL6258419

SCHEMBL6258419

Cn1c(=O)n(Cc2ccccc2)c(=O)c2c(C(=O)OCCCc3ccccn3)csc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.42
ERCC5 P28715 1/20 0.39
FEN1 P39748 1/20 0.39
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
CHRM5 P08912 1/20 0.38
CHRM1 P11229 1/20 0.38
ADORA2B P29275 4/20 0.37
LMNA P02545 1/20 0.37
TSHR P16473 1/20 0.37
MAPK1 P28482 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
POLB P06746 1/20 0.37
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CYP3A4 P08684 1/20 0.36
MAPT P10636 1/20 0.36
HPGD P15428 1/20 0.36
HSD17B10 Q99714 1/20 0.36
ADORA3 P0DMS8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7099112 0.95 TRPA1 (0.43) TRPA1ERCC5FEN1MEN1KMT2A
SCHEMBL6470623 0.89 ADORA2B (0.42) ERCC5FEN1MEN1KMT2ACHRM5
SCHEMBL6254638 0.86 ADORA2B (0.46) TRPA1ERCC5FEN1MEN1KMT2A
SCHEMBL6473393 0.85 TSHR (0.47) ERCC5FEN1MEN1KMT2ALMNA
SCHEMBL6474542 0.85 ADORA2B (0.44) ERCC5FEN1MEN1KMT2AADORA2B
SCHEMBL6471776 0.85 TSHR (0.45) ERCC5FEN1MEN1KMT2ALMNA
SCHEMBL6465348 0.83 CHRM5 (0.45) MEN1KMT2ACHRM5CHRM1ADORA2B
SCHEMBL6470949 0.83 POLB (0.42) ERCC5FEN1MEN1KMT2AADORA2B
SCHEMBL6472052 0.82 MEN1 (0.44) ERCC5FEN1MEN1KMT2AADORA2B
SCHEMBL7024881 0.81 SCN1A (0.48) ERCC5FEN1MEN1KMT2ACHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1530467-A2 COMBINATION OF AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB Warner-Lambert Company LLC (US) 2005-05-18 EP disclosed
EP-1530475-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 Warner-Lambert Company LLC (US) 2005-05-18 EP disclosed
WO-2004006912-A2 COMBINATION OF AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed
WO-2004006931-A2 PHARMACEUTICAL COMPOSTIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed
EP-1370562-A1 THIENO[2,3-D]PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS Warner-Lambert Company LLC (US) 2003-12-17 EP disclosed
WO-2002064598-A1 THIENO'2,3-D PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2002-08-22 WO disclosed