SCHEMBL6465348

SCHEMBL6465348

COc1ccc(CCCOC(=O)c2csc3c2c(=O)n(Cc2ccccc2)c(=O)n3C)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM5 P08912 3/20 0.45
CHRM1 P11229 3/20 0.45
CHRM2 P08172 1/20 0.44
CHRM4 P08173 1/20 0.44
CHRM3 P20309 1/20 0.44
TP53 P04637 1/20 0.41
POLB P06746 1/20 0.41
ADORA2B P29275 2/20 0.40
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
MAPT P10636 2/20 0.40
ALDH1A1 P00352 2/20 0.40
LMNA P02545 2/20 0.40
MITF O75030 1/20 0.40
PKM P14618 1/20 0.40
MAPK1 P28482 1/20 0.40
PAX8 Q06710 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
HDAC1 Q13547 2/20 0.39
HDAC8 Q9BY41 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6470623 0.94 ADORA2B (0.42) CHRM5CHRM1CHRM2CHRM4CHRM3
SCHEMBL6476368 0.89 MEN1 (0.44) CHRM5CHRM1TP53POLBMEN1
SCHEMBL6473393 0.88 TSHR (0.47) TP53POLBMEN1KMT2AMAPT
SCHEMBL6474542 0.88 ADORA2B (0.44) TP53POLBADORA2BMEN1KMT2A
SCHEMBL6471149 0.85 LMNA (0.45) CHRM5CHRM1CHRM2CHRM4CHRM3
SCHEMBL6471776 0.85 TSHR (0.45) TP53POLBMEN1KMT2AMAPT
SCHEMBL6254638 0.85 ADORA2B (0.46) ADORA2BMEN1KMT2AMAPTALDH1A1
SCHEMBL6258419 0.83 TRPA1 (0.42) CHRM5CHRM1POLBADORA2BMEN1
SCHEMBL6470949 0.83 POLB (0.42) POLBADORA2BMEN1KMT2AMAPT
SCHEMBL6253632 0.83 MEN1 (0.43) TP53POLBMEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1530475-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 Warner-Lambert Company LLC (US) 2005-05-18 EP disclosed
WO-2004006931-A2 PHARMACEUTICAL COMPOSTIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed
EP-1370562-A1 THIENO[2,3-D]PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS Warner-Lambert Company LLC (US) 2003-12-17 EP disclosed
WO-2002064598-A1 THIENO'2,3-D PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2002-08-22 WO disclosed