Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6258419 | 0.95 | TRPA1 (0.42) | TRPA1CHRM5CHRM1ERCC5FEN1 | |
| SCHEMBL6474542 | 0.89 | ADORA2B (0.44) | ERCC5FEN1MEN1KMT2AADORA2B | |
| SCHEMBL6470623 | 0.85 | ADORA2B (0.42) | CHRM5CHRM1ERCC5FEN1MEN1 | |
| SCHEMBL6471149 | 0.84 | LMNA (0.45) | TRPA1CHRM5CHRM1ERCC5FEN1 | |
| SCHEMBL6470949 | 0.84 | POLB (0.42) | ERCC5FEN1MEN1KMT2AADORA2B | |
| SCHEMBL6476499 | 0.84 | MEN1 (0.40) | ERCC5FEN1MEN1KMT2AADORA2B | |
| SCHEMBL6472052 | 0.83 | MEN1 (0.44) | ERCC5FEN1MEN1KMT2AADORA2B | |
| SCHEMBL6473393 | 0.83 | TSHR (0.47) | ERCC5FEN1MEN1KMT2APOLB | |
| SCHEMBL6471284 | 0.83 | MEN1 (0.46) | ERCC5FEN1MEN1KMT2AADORA2B | |
| SCHEMBL6254638 | 0.82 | ADORA2B (0.46) | TRPA1ERCC5FEN1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370562-A1 | THIENO[2,3-D]PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002064598-A1 | THIENO'2,3-D PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | disclosed |