Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 5/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6259172 | 0.84 | SLC6A4 (0.47) | SLC6A4SLC6A2SMN1; SMN2L3MBTL1SLC6A3 | |
| SCHEMBL6262892 | 0.82 | SLC6A4 (0.45) | SLC6A4SLC6A2SLC6A3CYP2D6TSPO | |
| SCHEMBL6260236 | 0.76 | HCAR3 (0.51) | SLC6A4SLC6A2SLC6A3CYP2D6TSPO | |
| SCHEMBL8154853 | 0.74 | PTGER1 (0.46) | LMNA | |
| SCHEMBL6257686 | 0.74 | TSPO (0.43) | SLC6A4SLC6A2L3MBTL1SLC6A3TSPO | |
| SCHEMBL6261423 | 0.66 | L3MBTL1 (0.38) | SLC6A4L3MBTL1CYP2D6 | |
| SCHEMBL327806 | 0.65 | SLC6A4 (0.63) | SLC6A4SLC6A2L3MBTL1SLC6A3LMNA | |
| SCHEMBL6260558 | 0.65 | AOC3 (0.41) | SMN1; SMN2L3MBTL1 | |
| Butane SCHEMBL6289475 | 0.65 | CTNNB1 (0.51) | SMN1; SMN2L3MBTL1TSPOLMNAMAPT | |
| Hydrogen Sulfide SCHEMBL28150140 | 0.64 | SLC6A4 (0.61) | SLC6A4SLC6A2L3MBTL1SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752421-B1 | Ortho-substituted aromatic compounds, containing three (het)aryl moieties, their preparation and their use as prostaglandin E2-(PGE2)-antagonists | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | EP | claimed |