Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.53 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.40 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625934 | 1.00 | GABRA1 (0.53) | GABRA1GABRG2GABRB3GABRB2GABRB1 | |
| SCHEMBL625933 | 1.00 | GABRA1 (0.53) | GABRA1GABRG2GABRB3GABRB2GABRB1 | |
| SCHEMBL16992768 | 0.81 | MAPT (0.46) | GABRA1GABRG2GABRB3GABRB2GABRB1 | |
| SCHEMBL11761840 | 0.81 | GABRA1 (0.58) | GABRA1GABRG2GABRB3GABRB2GABRB1 | |
| SCHEMBL16992767 | 0.81 | MAPT (0.46) | GABRA1GABRG2GABRB3GABRB2GABRB1 | |
| SCHEMBL25342763 | 0.81 | GABRA1 (0.58) | GABRA1GABRG2GABRB3GABRB2GABRB1 | |
| SCHEMBL16992765 | 0.81 | MAPT (0.46) | GABRA1GABRG2GABRB3GABRB2GABRB1 | |
| SCHEMBL11763446 | 0.81 | GABRA1 (0.58) | GABRA1GABRG2GABRB3GABRB2GABRB1 | |
| SCHEMBL14189755 | 0.80 | PDE4A (0.55) | GABRA1GABRG2GABRB3GABRB2ALDH1A1 | |
| SCHEMBL8548467 | 0.80 | PDE4A (0.49) | GABRA1GABRG2GABRB3GABRB2GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017004025-A1 | CONJUGATES OF CYSTEINE ENGINEERED ANTIBODIES | IMMUNOGEN, INC. (US) | 2017-01-05 | — | — | WO | disclosed |
| US-9156788-B2 | TRPV3 modulators | ABBVIE INC. (US) | 2015-10-13 | — | — | US | disclosed |
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| US-20130150409-A1 | NOVEL TRPV3 MODULATORS | ABBVIE INC. (US) | 2013-06-13 | — | — | US | disclosed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150409-A1 | NOVEL TRPV3 MODULATORS | TRPV3, TRPV4, TRPV5 | GABRA1 1334/4885GABRG2 1651/4885GABRB3 716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.