Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18857270 | 0.83 | THRA (0.38) | HCAR2GPR84THRATHRBTSHR | |
| SCHEMBL4706518 | 0.83 | — | — | |
| SCHEMBL1436798 | 0.76 | TAAR1 (0.32) | — | |
| SCHEMBL27378739 | 0.76 | TYR (0.37) | HCAR2HCAR3TSHRMAPT | |
| SCHEMBL370841 | 0.76 | TDP1 (0.35) | HCAR2HCAR3TSHRMAPT | |
| SCHEMBL28300224 | 0.74 | LIPG (0.38) | HCAR2GPR84TSHRMAPT | |
| SCHEMBL28300226 | 0.74 | LIPG (0.38) | HCAR2GPR84TSHRMAPT | |
| SCHEMBL1880278 | 0.74 | ALOX5 (0.44) | HIF1AHCAR2HCAR3TSHRMAPT | |
| SCHEMBL31013116 | 0.74 | TYR (0.40) | HCAR2GPR84THRBTSHRMAPT | |
| SCHEMBL544780 | 0.74 | TLR8 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581521-A1 | FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004063190-A1 | FUSED HETEROCYCLIC DERIVATES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |