Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624920 | 0.87 | PIK3CA (0.46) | PIK3CAPIK3CDRIPK1CDK2 | |
| SCHEMBL626581 | 0.84 | FYN (0.47) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL625652 | 0.84 | PIK3CA (0.49) | PIK3CAPIK3CDPIK3CBMAP3K12 | |
| SCHEMBL626134 | 0.84 | PIK3CA (0.50) | PIK3CAPIK3CDPIK3CBPIK3CGRIPK1 | |
| SCHEMBL625280 | 0.83 | PIK3CA (0.49) | PIK3CAMAP3K12 | |
| SCHEMBL625862 | 0.81 | PIK3CA (0.47) | PIK3CAPIK3CDPIK3CBPIK3CGMAP3K12 | |
| SCHEMBL624427 | 0.76 | PIK3CA (0.50) | PIK3CAMAP3K12 | |
| SCHEMBL627329 | 0.75 | PIK3CA (0.49) | PIK3CA | |
| SCHEMBL627327 | 0.75 | PIK3CA (0.49) | PIK3CA | |
| SCHEMBL626006 | 0.73 | PIK3CA (0.46) | PIK3CAPIK3CDPIK3CBPIK3CGRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |