Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.49 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.38 |
| ▸ | FYN | P06241 | 3/20 | 0.36 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625280 | 0.86 | PIK3CA (0.49) | PIK3CAMAP3K12 | |
| SCHEMBL625862 | 0.86 | PIK3CA (0.47) | PIK3CAMAP3K12FYNPIK3CDPIK3CB | |
| SCHEMBL626133 | 0.84 | PIK3CA (0.47) | PIK3CAMAP3K12PIK3CDPIK3CB | |
| SCHEMBL625235 | 0.84 | FYN (0.52) | PIK3CAFYN | |
| SCHEMBL624920 | 0.82 | PIK3CA (0.46) | PIK3CAPIK3CD | |
| SCHEMBL626701 | 0.81 | MKNK1 (0.52) | PIK3CAFYN | |
| SCHEMBL625653 | 0.78 | PIK3CA (0.54) | PIK3CAMAP3K12 | |
| SCHEMBL626700 | 0.78 | PIK3CA (0.52) | PIK3CAMAP3K12 | |
| SCHEMBL625674 | 0.76 | PIK3CA (0.50) | PIK3CAMAP3K12FYN | |
| SCHEMBL624388 | 0.75 | PIK3CA (0.55) | PIK3CAMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |