Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.31 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.30 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627849 | 0.80 | FYN (0.46) | PIM1KCNH2 | |
| SCHEMBL626162 | 0.79 | CD38 (0.34) | PIM1KCNH2VNN1BMPR1BBMPR1A | |
| SCHEMBL625280 | 0.76 | PIK3CA (0.49) | PIM1KCNH2BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL625009 | 0.72 | HSD11B1 (0.31) | PIM1KCNH2 | |
| SCHEMBL627018 | 0.63 | FYN (0.47) | — | |
| SCHEMBL1650183 | 0.62 | DCTPP1 (0.37) | — | |
| SCHEMBL627199 | 0.62 | FYN (0.46) | — | |
| SCHEMBL2588468 | 0.61 | OPRM1 (0.61) | — | |
| SCHEMBL627850 | 0.59 | JAK1 (0.35) | PIM1KCNH2 | |
| SCHEMBL628002 | 0.59 | PIM1 (0.38) | PIM1KCNH2HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |