Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | STAT6 | P42226 | 1/20 | 0.76 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.76 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.76 |
| ▸ | HEXA | P06865 | 6/20 | 0.72 |
| ▸ | HEXB | P07686 | 6/20 | 0.72 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | AHR | P35869 | 1/20 | 0.64 |
| ▸ | RAD52 | P43351 | 1/20 | 0.64 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.64 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | OGA | O60502 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8396166 | 0.93 | LCK (0.73) | POLBMEN1KMT2ACYP1A2TNNI3 | |
| SCHEMBL1569105 | 0.91 | POLB (0.74) | POLBMEN1KMT2ACYP1A2TNNI3 | |
| SCHEMBL9720969 | 0.90 | ALDH1A1 (0.66) | POLBMEN1KMT2ACYP1A2TNNI3 | |
| SCHEMBL18017612 | 0.89 | POLB (0.77) | POLBMEN1KMT2ACYP1A2TNNI3 | |
| SCHEMBL6272273 | 0.87 | POLB (1.00) | POLBMEN1KMT2ACYP1A2TNNI3 | |
| SCHEMBL12672650 | 0.87 | LCK (0.65) | POLBMEN1KMT2ACYP1A2TNNI3 | |
| SCHEMBL14864819 | 0.86 | HEXA (0.75) | POLBMEN1KMT2ACYP1A2TNNI3 | |
| SCHEMBL30272534 | 0.86 | TERT (0.59) | POLBMEN1KMT2ACYP1A2TNNI3 | |
| SCHEMBL8393458 | 0.85 | LCK (0.76) | POLBMEN1KMT2ACYP1A2TNNI3 | |
| SCHEMBL929729 | 0.85 | MAOB (0.77) | POLBMEN1KMT2ACYP1A2TNNI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140336178-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | THE GENERAL HOSPITAL CORPORATION (US) | 2014-11-13 | — | — | US | disclosed |
| US-20140336178-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | THE GENERAL HOSPITAL CORPORATION (US) | 2014-11-13 | — | — | US | disclosed |
| US-20140336178-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | THE GENERAL HOSPITAL CORPORATION (US) | 2014-11-13 | — | — | US | disclosed |
| US-20130203733-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130203733-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130203733-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-08-08 | — | — | US | disclosed |
| US-8404747-B2 | Compositions and methods for modulating interaction between polypeptides | THE GENERAL HOSPITAL CORPORATION (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404747-B2 | Compositions and methods for modulating interaction between polypeptides | THE GENERAL HOSPITAL CORPORATION (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404747-B2 | Compositions and methods for modulating interaction between polypeptides | THE GENERAL HOSPITAL CORPORATION (US) | 2013-03-26 | — | — | US | disclosed |
| US-20050239833-A1 | Compositions and methods for modulating interaction between polypeptides | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2005-10-27 | — | — | US | disclosed |
| WO-2005087217-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | THE GENERAL HOSPITAL CORPORATION (US) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239833-A1 | Compositions and methods for modulating interaction between polypeptides | IAPP, SERPINA6, SERPINA2 | POLB 3663/4885MEN1 1736/4885KMT2A 4744/4885 |
| US-20130203733-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | IAPP, SERPINA6, SERPINA2 | POLB 3663/4885MEN1 1736/4885KMT2A 4744/4885 |
| US-20140336178-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | IAPP, SERPINA6, SERPINA2 | POLB 3663/4885MEN1 1736/4885KMT2A 4744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.