Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.73 |
| ▸ | HEXA | P06865 | 6/20 | 0.67 |
| ▸ | HEXB | P07686 | 6/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | STAT6 | P42226 | 1/20 | 0.67 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.67 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.63 |
| ▸ | AHR | P35869 | 1/20 | 0.63 |
| ▸ | RAD52 | P43351 | 1/20 | 0.63 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.63 |
| ▸ | BCHE | P06276 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12672650 | 0.94 | LCK (0.65) | LCKHEXAHEXBPOLBMEN1 | |
| SCHEMBL6263721 | 0.93 | POLB (0.76) | LCKHEXAHEXBPOLBMEN1 | |
| SCHEMBL12660268 | 0.90 | LCK (0.61) | LCKHEXAHEXBPOLBMEN1 | |
| SCHEMBL8393458 | 0.90 | LCK (0.76) | LCKHEXAHEXBPOLBMEN1 | |
| SCHEMBL1569105 | 0.90 | POLB (0.74) | LCKHEXAHEXBPOLBMEN1 | |
| SCHEMBL9720969 | 0.83 | ALDH1A1 (0.66) | LCKHEXAHEXBPOLBMEN1 | |
| SCHEMBL14864819 | 0.82 | HEXA (0.75) | LCKHEXAHEXBPOLBMEN1 | |
| SCHEMBL8620098 | 0.82 | HEXA (0.75) | LCKHEXAHEXBPOLBMEN1 | |
| SCHEMBL18017612 | 0.82 | POLB (0.77) | LCKHEXAHEXBPOLBMEN1 | |
| SCHEMBL14463932 | 0.82 | LCK (0.64) | LCKHEXAHEXBPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981753-A | Bis-naphthalimides for the treatment of cancer | BASF AKTIENGESELLSCHAFT (DE) | 1999-11-09 | — | — | US | disclosed |
| US-5789418-A | Bis-naphthalimides for the treatment of cancer | BASF AKTIENGESELLSCHAFT (DE) | 1998-08-04 | — | — | US | disclosed |
| EP-0714387-B1 | NEW BIS-NAPHTHALIMIDES FOR THE TREATMENT OF CANCER | BASF AG (DE) | 1998-05-27 | — | — | EP | disclosed |
| US-5616589-A | Bis-naphthalimides for the treatment of cancer | BASF AKTIENGESELLSCHAFT (DE) | 1997-04-01 | — | — | US | disclosed |
| EP-0714387-A1 | NEW BIS-NAPHTHALIMIDES FOR THE TREATMENT OF CANCER | BASF AKTIENGESELLSCHAFT (DE) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005365-A1 | NEW BIS-NAPHTHALIMIDES FOR THE TREATMENT OF CANCER | BASF AKTIENGESELLSCHAFT (DE) | 1995-02-23 | — | — | WO | disclosed |