Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.36 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6261777 | 1.00 | GRIK1 (0.41) | GRIK1GRIK2GPR84FFAR1MAPT | |
| Hydrochloric Acid SCHEMBL6353061 | 0.98 | GRIK1 (0.41) | GRIK1GRIK2GPR84FFAR1MAPT | |
| Hydrochloric Acid SCHEMBL6345432 | 0.98 | GRIK1 (0.41) | GRIK1GRIK2GPR84FFAR1MAPT | |
| SCHEMBL6261769 | 0.98 | MAPT (0.41) | GRIK1GRIK2GPR84FFAR1MAPT | |
| Hydrochloric Acid SCHEMBL6344395 | 0.97 | MAPT (0.40) | GRIK1GRIK2GPR84FFAR1MAPT | |
| SCHEMBL6260613 | 0.92 | GRIK1 (0.41) | GRIK1GRIK2GPR84FFAR1MAPT | |
| Hydrochloric Acid SCHEMBL6351495 | 0.91 | GRIK1 (0.40) | GRIK1GRIK2GPR84FFAR1MAPT | |
| SCHEMBL6261457 | 0.89 | GRIK1 (0.41) | GRIK1GRIK2GPR84FFAR1MAPT | |
| Hydrochloric Acid SCHEMBL6340915 | 0.88 | GRIK1 (0.40) | GRIK1GRIK2GPR84FFAR1MAPT | |
| SCHEMBL6265356 | 0.81 | KIF11 (0.44) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317426-B1 | BETA-THIO-AMINO ACIDS | GRUENENTHAL GMBH (DE) | 2005-11-16 | — | — | EP | claimed |
| US-6846843-B2 | Gabapentin; antiepileptic agents, analgesics | GRUENENTHAL GMBH (DE) | 2005-01-25 | — | — | US | claimed |
| US-20030236253-A1 | Beta-thioamino acids | GRUENENTHAL GMBH (DE) | 2003-12-25 | — | — | US | claimed |
| EP-1317426-A1 | BETA-THIO-AMINO ACIDS | Grünenthal GmbH (DE) | 2003-06-11 | — | — | EP | claimed |
| WO-2002022568-A1 | ss-THIO-AMINO ACIDS | Grünenthal GmbH (DE) | 2002-03-21 | — | — | WO | claimed |
| EP-1317426-B1 | BETA-THIO-AMINO ACIDS | GRUENENTHAL GMBH (DE) | 2005-11-16 | — | — | EP | disclosed |
| US-6846843-B2 | Gabapentin; antiepileptic agents, analgesics | GRUENENTHAL GMBH (DE) | 2005-01-25 | — | — | US | disclosed |
| US-20030236253-A1 | Beta-thioamino acids | GRUENENTHAL GMBH (DE) | 2003-12-25 | — | — | US | disclosed |
| EP-1317426-A1 | BETA-THIO-AMINO ACIDS | Grünenthal GmbH (DE) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002022568-A1 | ss-THIO-AMINO ACIDS | Grünenthal GmbH (DE) | 2002-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236253-A1 | Beta-thioamino acids | TPMT, OPRD1, TST | GRIK1 593/4885GRIK2 938/4885GPR84 2001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.