Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.72 |
| ▸ | DRD3 | P35462 | 4/20 | 0.72 |
| ▸ | HTR1A | P08908 | 5/20 | 0.68 |
| ▸ | HTR7 | P34969 | 4/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.68 |
| ▸ | DRD4 | P21917 | 2/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6238933 | 0.92 | DRD2 (0.72) | DRD2DRD3HTR1AHTR7ADRA1A | |
| SCHEMBL11083371 | 0.87 | HTR1A (0.72) | DRD2DRD3HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL11089079 | 0.85 | HTR1A (0.72) | DRD2HTR1AHTR7 | |
| SCHEMBL3162960 | 0.84 | DRD2 (0.76) | DRD2DRD3DRD4 | |
| SCHEMBL14761584 | 0.81 | DRD2 (0.94) | DRD2DRD3HTR1AADRA1ADRD4 | |
| SCHEMBL19580052 | 0.81 | DRD2 (0.81) | DRD2DRD3HTR1AADRA1ADRD4 | |
| SCHEMBL9653869 | 0.81 | DRD2 (0.78) | DRD2DRD3HTR1AADRA1ADRD4 | |
| SCHEMBL7869518 | 0.81 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL27966706 | 0.81 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL7703653 | 0.80 | DRD2 (0.83) | DRD2DRD3HTR1AHTR7ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005018643-A1 | METABOLITES OF 1-{3-4`4-(2-METHOXYPHENYL) PIPERAZIN-1-YL!-PROPYL}-PIPERIDINE-2, 6-DIONE FOR USE IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | RANBAXY LABORATORIES LIMITED (IN) | 2005-03-03 | — | — | WO | claimed |
| WO-2005018643-A1 | METABOLITES OF 1-{3-4`4-(2-METHOXYPHENYL) PIPERAZIN-1-YL!-PROPYL}-PIPERIDINE-2, 6-DIONE FOR USE IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | RANBAXY LABORATORIES LIMITED (IN) | 2005-03-03 | — | — | WO | disclosed |