Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.83 |
| ▸ | DRD3 | P35462 | 2/20 | 0.83 |
| ▸ | HTR1A | P08908 | 2/20 | 0.68 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.67 |
| ▸ | DRD4 | P21917 | 1/20 | 0.66 |
| ▸ | HTR7 | P34969 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9652838 | 0.89 | DRD2 (0.69) | DRD2DRD3HTR1AADRA1ADRD4 | |
| SCHEMBL7703066 | 0.82 | DRD2 (0.85) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL6238933 | 0.82 | DRD2 (0.72) | DRD2DRD3HTR1AADRA1ADRD4 | |
| SCHEMBL9653869 | 0.82 | DRD2 (0.78) | DRD2DRD3HTR1AADRA1ADRD4 | |
| SCHEMBL14007328 | 0.81 | HTR7 (0.69) | DRD2DRD3HTR1AHTR7 | |
| SCHEMBL5442134 | 0.81 | ADRA1D (1.00) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL8446460 | 0.80 | DRD2 (0.85) | DRD2HTR1AADRA1ADRD4 | |
| SCHEMBL6264690 | 0.80 | DRD2 (0.72) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL9652768 | 0.79 | ALDH1A1 (0.63) | DRD2DRD3HTR1AADRA1ADRD4 | |
| SCHEMBL23054969 | 0.79 | MAPK1 (0.63) | DRD2DRD3ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344458-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | AMERICAN HOME PRODUCTS CORPORATION | 2002-02-05 | — | — | US | disclosed |