Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | KLK7 | P49862 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.30 |
| ▸ | SPR | P35270 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6768044 | 0.77 | GRIN2D (0.41) | GAAMEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL2539046 | 0.71 | GPR84 (0.37) | MAPTMEN1KMT2AADRA1AKDM4E | |
| SCHEMBL24197894 | 0.70 | ADRA1A (0.32) | MAPTALDH1A1ADRA1AKDM4E | |
| SCHEMBL24198524 | 0.67 | KDM4E (0.43) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL6763499 | 0.66 | GAA (0.58) | GAAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL18358661 | 0.65 | DAO (0.46) | GAAMAPTMEN1KMT2A | |
| SCHEMBL6768239 | 0.65 | GRIN2D (0.42) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL12172451 | 0.64 | KDM5A (0.36) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL8808057 | 0.63 | KDM4E (0.57) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8831920 | 0.62 | SCN9A (0.33) | MAPTMEN1KMT2AALDH1A1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |