Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2639776 | 0.83 | ALDH1A1 (0.46) | SIGMAR1OPRM1OPRD1SLC22A1CHRM1 | |
| SCHEMBL18428973 | 0.81 | ALDH1A1 (0.45) | SIGMAR1CHRM1CHRM3ALDH1A1POLB | |
| SCHEMBL4142245 | 0.81 | ALDH1A1 (0.47) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL1325734 | 0.80 | OPRM1 (0.43) | SIGMAR1OPRM1OPRD1ALDH1A1POLB | |
| SCHEMBL8544469 | 0.79 | ALDH1A1 (0.45) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL11239286 | 0.79 | OPRM1 (0.40) | SIGMAR1OPRM1OPRD1SLC22A1NR1I2 | |
| SCHEMBL3964785 | 0.78 | ALDH1A1 (0.45) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL28026626 | 0.76 | ALDH1A1 (0.42) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL28275930 | 0.76 | OPRM1 (0.38) | SIGMAR1OPRM1OPRD1SLC22A1NR1I2 | |
| SCHEMBL12473807 | 0.73 | ALDH1A1 (0.41) | ALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190117637-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATMENT OF PAIN | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-04-25 | — | — | US | disclosed |
| EP-1411942-A4 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | SYNAPTIC PHARMA CORP (US) | 2005-01-26 | — | — | EP | disclosed |
| EP-1411942-A1 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | Synaptic Pharmaceutical Corporation (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003004027-A1 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2003-01-16 | — | — | WO | disclosed |
| US-5214148-A | Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides | GLAXO INC. (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0396282-A2 | N-aryl-N-[4-(heterocyclicalkyl) piperidinyl]amides and pharmaceutical compositions and methods employing such compounds | BOC, INC. (US) | 1990-11-07 | — | — | EP | disclosed |