Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.47 |
| ▸ | MMP13 | P45452 | 15/20 | 0.47 |
| ▸ | MMP2 | P08253 | 8/20 | 0.43 |
| ▸ | MMP14 | P50281 | 5/20 | 0.43 |
| ▸ | MMP9 | P14780 | 4/20 | 0.40 |
| ▸ | MMP1 | P03956 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3949307 | 0.81 | MMP13 (0.67) | ADAM17MMP13MMP2MMP14MMP9 | |
| SCHEMBL3949076 | 0.81 | ADAM17 (0.47) | ADAM17MMP13MMP2MMP14MMP9 | |
| SCHEMBL6268549 | 0.79 | ADAM17 (0.52) | ADAM17MMP13MMP2MMP14MMP9 | |
| SCHEMBL3949527 | 0.78 | ADAM17 (0.62) | ADAM17MMP13MMP2MMP14MMP9 | |
| SCHEMBL3948423 | 0.72 | ADAM17 (0.68) | ADAM17MMP13MMP2MMP14MMP9 | |
| SCHEMBL6264627 | 0.69 | ADAM17 (0.45) | ADAM17MMP13MMP2MMP14MMP9 | |
| SCHEMBL6261987 | 0.69 | ADAM17 (0.71) | ADAM17MMP13MMP2MMP14MMP9 | |
| SCHEMBL6694069 | 0.68 | ADAM17 (0.62) | ADAM17MMP13MMP2MMP14MMP9 | |
| SCHEMBL7394890 | 0.66 | ADAM17 (0.52) | ADAM17MMP13MMP2MMP14MMP9 | |
| SCHEMBL6263128 | 0.64 | ADAM17 (0.55) | ADAM17MMP13MMP2MMP14MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147085-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | WYETH CORP (US) | 2005-11-16 | — | — | EP | disclosed |
| US-6753337-B2 | INHIBITORS OF TNF-ALPHA CONVERTING ENZYME; TREATMENT OF ARTHRITIS, INFLAMMATION, INFLAMMATORY BOWEL DISEASE ETC, | WYETH HOLDINGS CORPORATION | 2004-06-22 | — | — | US | disclosed |
| US-6358980-B1 | FOR THERAPY OF ARTHRITIS, TUMOR METASTASIS, TISSUE ULCERATION, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, DIABETES (INSULIN RESISTANCE) AND HIV INFECTION | AMERICAN CYANAMID COMPANY | 2002-03-19 | — | — | US | disclosed |
| EP-1147085-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044723-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS/TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |