SCHEMBL6270065

SCHEMBL6270065

COc1c(C)ccc2[nH]ccc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RHEB Q15382 1/20 0.41
▸ TUBB4A P04350 5/20 0.40
▸ TUBB P07437 5/20 0.40
▸ TUBA3C P0DPH7 5/20 0.40
▸ TUBA1B P68363 5/20 0.40
▸ TUBA4A P68366 5/20 0.40
▸ TUBB4B P68371 5/20 0.40
▸ TUBB3 Q13509 5/20 0.40
▸ TUBB2A Q13885 5/20 0.40
▸ TUBB8 Q3ZCM7 5/20 0.40
▸ TUBA3E Q6PEY2 5/20 0.40
▸ TUBA1A Q71U36 5/20 0.40
▸ TUBA1C Q9BQE3 5/20 0.40
▸ TUBB6 Q9BUF5 5/20 0.40
▸ TUBB2B Q9BVA1 5/20 0.40
▸ TUBB1 Q9H4B7 5/20 0.40
▸ P2RX7 Q99572 1/20 0.40
▸ BRD4 O60885 1/20 0.40
▸ MTNR1A P48039 1/20 0.37
▸ MTNR1B P49286 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30483746 1.00 RHEB (0.41) RHEBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL38660362 0.80 TUBB4A (0.47) RHEBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL2979916 0.80 RHEB (0.41) RHEBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL2085433 0.80 TUBB4A (0.47) RHEBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL25748438 0.78 RHEB (0.40) RHEBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL30483766 0.78 RHEB (0.40) RHEBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL30712075 0.78 KDM4E (0.45) RHEBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL12034737 0.76 PARP1 (0.41) MAPK1KMT2AKDM4EALDH1A1
SCHEMBL8404367 0.74 AHR (0.40) RHEBP2RX7BRD4AHR
SCHEMBL12309699 0.73 BRD4 (0.41) RHEBTUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250101038-A1 COMPOUNDS Psylo Pty Ltd (AU) 2025-03-27 — — US disclosed
CN-118715204-A Compounds of formula (I) 普赛洛私人有限公司 2024-09-27 — — CN disclosed
WO-2023115166-A1 COMPOUNDS Psylo Pty Ltd (AU) 2023-06-29 — — WO disclosed
US-20170166561-A1 QUINUCLIDINE COMPOUNDS FOR MODULATING ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY ALPHARMAGEN LLC (US) 2017-06-15 — — US disclosed
US-20170166561-A1 QUINUCLIDINE COMPOUNDS FOR MODULATING ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY ALPHARMAGEN LLC (US) 2017-06-15 — — US disclosed
US-9434724-B2 Quinuclidines for modulating alpha 7 activity ALPHARMAGEN, LLC (US) 2016-09-06 — — US disclosed
US-9434724-B2 Quinuclidines for modulating alpha 7 activity ALPHARMAGEN, LLC (US) 2016-09-06 — — US disclosed
US-20160009706-A1 QUINUCLIDINES FOR MODULATING ALPHA 7 ACTIVITY ALPHARMAGEN, LLC 2016-01-14 — — US disclosed
US-20160009706-A1 QUINUCLIDINES FOR MODULATING ALPHA 7 ACTIVITY ALPHARMAGEN, LLC 2016-01-14 — — US disclosed
WO-2016007630-A1 QUINUCLIDINE COMPOUNDS FOR MODULATING ALPHA7 -NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY ALPHARMAGEN, LLC (US) 2016-01-14 — — WO disclosed
EP-1161418-B1 1-ACYL-7-NITROINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHOTOCLEAVABLE PRECURSORS MEDICAL RES COUNCIL (GB) 2005-12-28 — — EP disclosed
US-6765014-B1 DRUG DELIVERY OF NEUROACTIVE AMINO ACIDS OR METAL CHELATORS MEDICAL RESEARCH COUNCIL (GB) 2004-07-20 — — US disclosed
EP-1161418-A1 1-ACYL-7-NITROINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHOTOCLEAVABLE PRECURSORS MEDICAL RESEARCH COUNCIL (GB) 2001-12-12 — — EP disclosed
WO-2000055133-A1 1-ACYL-7-NITROINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHOTOCLEAVABLE PRECURSORS MEDICAL RESEARCH COUNCIL (GB) 2000-09-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250101038-A1 COMPOUNDS NLN, SLC18A2, PYGB RHEB 673/4885TUBB4A 627/4885TUBB 472/4885
US-20160009706-A1 QUINUCLIDINES FOR MODULATING ALPHA 7 ACTIVITY CHRNA7, CHRNA2, CHRNA5 RHEB 2671/4885TUBB4A 1075/4885TUBB 800/4885
US-20170166561-A1 QUINUCLIDINE COMPOUNDS FOR MODULATING ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY CHRNA7, CHRNA2, CHRNA6 RHEB 2940/4885TUBB4A 1449/4885TUBB 1150/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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