SCHEMBL6270230

SCHEMBL6270230

Nc1nc(OCc2cccc3ccccc23)c2[nH]cnc2n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PIN1 Q13526 9/20 1.00
MGMT P16455 9/20 0.67
CDK1 P06493 9/20 0.67
CCNB1 P14635 9/20 0.67
CCNA2 P20248 9/20 0.67
CDK2 P24941 9/20 0.67
CCNA1 P78396 9/20 0.67
LMNA P02545 1/20 0.67
CYP1A2 P05177 1/20 0.67
CYP3A4 P08684 1/20 0.67
CYP2D6 P10635 1/20 0.67
CYP2C9 P11712 1/20 0.67
TSHR P16473 1/20 0.67
NFKB1 P19838 1/20 0.67
CYP2C19 P33261 1/20 0.67
BLM P54132 1/20 0.67
PMP22 Q01453 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
6-O-Benzylguanine SCHEMBL61740 0.80 PIN1 (1.00) PIN1MGMTCDK1CCNB1CCNA2
6-O-Benzylguanine SCHEMBL31517079 0.80 PIN1 (1.00) PIN1MGMTCDK1CCNB1CCNA2
SCHEMBL6270225 0.80 PIN1 (0.67) PIN1MGMTCDK1CCNB1CCNA2
6-O-Benzylguanine SCHEMBL4631744 0.79 PIN1 (0.97) PIN1MGMTCDK1CCNB1CCNA2
SCHEMBL29378279 0.77 HTR3E (0.70) PIN1MGMTCDK1CCNB1CCNA2
SCHEMBL23124359 0.76 MGMT (0.81) PIN1MGMTCDK1CCNB1CCNA2
SCHEMBL29749175 0.76 MGMT (0.81) PIN1MGMTCDK1CCNB1CCNA2
6-O-Benzylguanine SCHEMBL4869639 0.75 PIN1 (0.88) PIN1MGMTCDK1CCNB1CCNA2
SCHEMBL3300787 0.74 PIN1 (0.76) PIN1MGMTCDK1CCNB1CCNA2
SCHEMBL23511144 0.74 PIN1 (1.00) PIN1MGMTCDK1CCNB1CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1017394-B1 CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES CANCER REC TECH LTD (GB) 2005-12-07 EP claimed
US-6303618-B1 ADMINISTERING PURINE COMPOUND WHICH INHIBITS CYCLIC DEPENDENT KINASE ACTIVITY FOR THERAPY OF TUMOR OR OTHER CELL PROLIFERATION DISORDER CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2001-10-16 US claimed
EP-1017394-B1 CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES CANCER REC TECH LTD (GB) 2005-12-07 EP disclosed
US-6303618-B1 ADMINISTERING PURINE COMPOUND WHICH INHIBITS CYCLIC DEPENDENT KINASE ACTIVITY FOR THERAPY OF TUMOR OR OTHER CELL PROLIFERATION DISORDER CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2001-10-16 US disclosed
WO-1999002162-A9 CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES CANCER RES CAMPAIGN TECH (GB) 1999-07-29 WO disclosed