Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625475 | 0.68 | PGR (0.57) | LMNAGRIN1PGRMAOBMAPT | |
| SCHEMBL625884 | 0.68 | PGR (0.40) | LMNAPGRBRD4GRM2 | |
| SCHEMBL625493 | 0.68 | PDE3B (0.43) | LMNAPDE3AALDH1A1 | |
| SCHEMBL625682 | 0.66 | GRM2 (0.42) | LMNAGRIN1PGRBRD4GRM2 | |
| SCHEMBL10146576 | 0.65 | GRM2 (0.64) | GRIN1MAOBBRD4GRM2GRIN2B | |
| SCHEMBL6268065 | 0.65 | BACE1 (0.57) | LMNAALDH1A1HTTMEN1MAPT | |
| SCHEMBL29249872 | 0.64 | KDM4E (0.54) | LMNAALDH1A1NPSR1BRD4MAPT | |
| SCHEMBL6268908 | 0.64 | KDM4E (0.50) | LMNAALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL31092665 | 0.64 | KDM4E (0.54) | LMNAALDH1A1NPSR1BRD4MAPT | |
| SCHEMBL625578 | 0.63 | CHEK1 (0.36) | LMNAPDE3APGRADORA2BADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | claimed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | claimed |