Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6268075 | 0.89 | ADORA2A (0.34) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6271387 | 0.79 | CDK1 (0.37) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6266771 | 0.76 | CDK1 (0.36) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6265529 | 0.75 | PDE4A (0.34) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2113436 | 0.74 | ADORA2A (0.33) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL874734 | 0.73 | ADORA2A (0.45) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1767742 | 0.73 | ADORA2A (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5503490 | 0.72 | ADORA2A (0.49) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL473734 | 0.72 | ADORA2A (0.32) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8343186 | 0.72 | HPRT1 (0.31) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017394-B1 | CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES | CANCER REC TECH LTD (GB) | 2005-12-07 | — | — | EP | disclosed |
| US-6303618-B1 | ADMINISTERING PURINE COMPOUND WHICH INHIBITS CYCLIC DEPENDENT KINASE ACTIVITY FOR THERAPY OF TUMOR OR OTHER CELL PROLIFERATION DISORDER | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2001-10-16 | — | — | US | disclosed |
| EP-1017394-A1 | CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999002162-A9 | CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES | CANCER RES CAMPAIGN TECH (GB) | 1999-07-29 | — | — | WO | disclosed |
| WO-1999002162-A1 | CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1999-01-21 | — | — | WO | disclosed |