Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 9/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628264 | 0.95 | BTK (0.51) | BTKJAK3CTSKPDE10AMAP4K4 | |
| SCHEMBL627226 | 0.94 | CKS1B (0.46) | BTKJAK3CTSKPDE10ASUV39H2 | |
| SCHEMBL626887 | 0.81 | CKS1B (0.48) | SUV39H2CKS1BSKP1SKP2 | |
| SCHEMBL626211 | 0.81 | IRAK1 (0.48) | SUV39H2CKS1BSKP1SKP2 | |
| SCHEMBL627192 | 0.80 | BTK (0.45) | BTKJAK3CTSKPDE10ASUV39H2 | |
| SCHEMBL626399 | 0.78 | KDM1A (0.38) | BTKJAK3CTSKMAP4K4CKS1B | |
| SCHEMBL624991 | 0.77 | SYK (0.45) | BTKSUV39H2MAP4K4CKS1BSKP1 | |
| SCHEMBL628263 | 0.77 | BTK (0.52) | BTKJAK3CTSKPDE10AMAP4K4 | |
| SCHEMBL627265 | 0.76 | CKS1B (0.41) | MAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL23583209 | 0.75 | CTSK (0.50) | BTKJAK3CTSKPDE10ASUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |