Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 14/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL626887 | 0.90 | CKS1B (0.48) | IRAK1MAPTTHRBSUV39H2CKS1B | |
| SCHEMBL628264 | 0.84 | BTK (0.51) | MAPTPOLBTHRB | |
| SCHEMBL626210 | 0.83 | IRAK1 (0.47) | IRAK1PRMT5THRBLMNATP53 | |
| SCHEMBL627193 | 0.81 | BTK (0.46) | SUV39H2CKS1BSKP1SKP2 | |
| SCHEMBL627226 | 0.79 | CKS1B (0.46) | MAPTSUV39H2CKS1BSKP1SKP2 | |
| SCHEMBL803637 | 0.73 | IRAK1 (0.49) | IRAK1PRMT5SUV39H2CKS1BSKP1 | |
| SCHEMBL627265 | 0.73 | CKS1B (0.41) | MAPTLMNACKS1BSKP1SKP2 | |
| SCHEMBL10232262 | 0.73 | NAMPT (0.55) | IRAK1MAPTPRMT5CKS1BSKP1 | |
| SCHEMBL627207 | 0.72 | OPRM1 (0.39) | — | |
| SCHEMBL626663 | 0.72 | BCHE (0.42) | SUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |