Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.51 |
| ▸ | JAK3 | P52333 | 3/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
| ▸ | RET | P07949 | 3/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627193 | 0.95 | BTK (0.46) | BTKJAK3MAP4K4PDE10ACTSK | |
| SCHEMBL627226 | 0.89 | CKS1B (0.46) | BTKJAK3MAP4K4PDE10ARET | |
| SCHEMBL626211 | 0.84 | IRAK1 (0.48) | MAPTTHRBPOLB | |
| SCHEMBL628263 | 0.82 | BTK (0.52) | BTKJAK3MAP4K4PDE10ACA1 | |
| SCHEMBL624017 | 0.79 | MAPT (0.49) | BTKMAPTTHRBPOLB | |
| SCHEMBL626887 | 0.78 | CKS1B (0.48) | MAPTTHRB | |
| SCHEMBL626399 | 0.78 | KDM1A (0.38) | BTKJAK3MAP4K4CA1CA2 | |
| SCHEMBL21737994 | 0.77 | BTK (0.52) | BTKJAK3MAP4K4PDE10ACA1 | |
| SCHEMBL17311358 | 0.75 | BTK (0.58) | BTKJAK3MAP4K4PDE10ACA1 | |
| SCHEMBL17311354 | 0.75 | BTK (0.58) | BTKJAK3MAP4K4PDE10ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |