Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627264 | 0.85 | CKS1B (0.43) | GPR119LMNATHRB | |
| SCHEMBL627512 | 0.82 | CKS1B (0.36) | USP30GPR119OPRM1OPRD1OGFRL1 | |
| SCHEMBL628406 | 0.81 | CYP11B2 (0.44) | GPR119LMNATHRB | |
| SCHEMBL627266 | 0.80 | CYP11B2 (0.41) | GPR119SPR | |
| SCHEMBL627207 | 0.78 | OPRM1 (0.39) | USP30NR1H2PDE10AGPR119OPRM1 | |
| SCHEMBL627208 | 0.78 | USP30 (0.33) | USP30NR1H2GPR119LMNA | |
| SCHEMBL627421 | 0.77 | RET (0.44) | — | |
| SCHEMBL929100 | 0.77 | USP30 (0.48) | USP30NR1H2PDE10AGPR119OPRM1 | |
| SCHEMBL627308 | 0.77 | PIK3CA (0.49) | USP30 | |
| SCHEMBL23268357 | 0.76 | RET (0.33) | PDE10ALMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |