Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.49 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625421 | 0.89 | PIK3CA (0.52) | PIK3CAMAP3K12RIPK1KCNH2 | |
| SCHEMBL627309 | 0.87 | MAP3K12 (0.46) | PIK3CAMAP3K12USP30 | |
| SCHEMBL626245 | 0.86 | PIK3CA (0.46) | PIK3CAMAP3K12RIPK1KCNH2 | |
| SCHEMBL627431 | 0.85 | PIK3CA (0.48) | PIK3CAKCNH2 | |
| SCHEMBL627019 | 0.84 | PIK3CA (0.47) | PIK3CAMAP3K12KCNH2HDAC1HDAC2 | |
| SCHEMBL626619 | 0.83 | PIK3CA (0.55) | PIK3CAMAP3K12KCNH2 | |
| SCHEMBL627310 | 0.82 | PIK3CA (0.46) | PIK3CAMAP3K12RIPK1 | |
| SCHEMBL626122 | 0.82 | PIK3CA (0.45) | PIK3CAKCNH2 | |
| SCHEMBL624990 | 0.80 | PIK3CA (0.47) | PIK3CARIPK1KCNH2 | |
| SCHEMBL625131 | 0.80 | PIK3CA (0.49) | PIK3CARIPK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |