Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 7/20 | 0.36 |
| ▸ | THRA | P10827 | 5/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PTAFR | P25105 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1642351 | 0.88 | THRB (0.47) | THRBTHRAPDE3BPDE3AMEN1 | |
| SCHEMBL6273257 | 0.83 | PDE3B (0.37) | THRBTHRAPDE3BPDE3AMEN1 | |
| SCHEMBL6268718 | 0.78 | THRB (0.46) | THRBTHRAALDH1A1 | |
| SCHEMBL6268739 | 0.78 | THRB (0.54) | THRBTHRA | |
| SCHEMBL6274873 | 0.78 | THRA (0.45) | THRBTHRAMEN1KMT2AKDM4E | |
| SCHEMBL6270966 | 0.78 | THRA (0.41) | THRBTHRA | |
| SCHEMBL6275008 | 0.77 | THRA (0.59) | THRBTHRA | |
| SCHEMBL6275027 | 0.76 | THRB (0.39) | THRBTHRAMEN1KMT2AHPGD | |
| SCHEMBL6272078 | 0.76 | THRA (0.42) | THRBTHRA | |
| SCHEMBL6273498 | 0.76 | THRB (0.52) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1297833-B1 | Indole carboxylic acids as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-12-21 | — | — | EP | claimed |