Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 8/20 | 0.45 |
| ▸ | THRB | P10828 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1642280 | 0.87 | THRA (0.49) | THRATHRBMAPTHTTKDM4E | |
| SCHEMBL6273680 | 0.84 | THRB (0.51) | THRATHRB | |
| SCHEMBL6275882 | 0.82 | THRA (0.51) | THRATHRB | |
| SCHEMBL6270950 | 0.82 | ALDH1A1 (0.44) | THRATHRBMAPTHTTKDM4E | |
| SCHEMBL6275290 | 0.82 | PTGS1 (0.40) | THRATHRBHTTKDM4EMEN1 | |
| SCHEMBL6270966 | 0.80 | THRA (0.41) | THRATHRB | |
| SCHEMBL6275008 | 0.79 | THRA (0.59) | THRATHRB | |
| SCHEMBL6272516 | 0.78 | THRB (0.36) | THRATHRBKDM4EMEN1KMT2A | |
| SCHEMBL6275373 | 0.76 | THRA (0.36) | THRATHRBMAPTHTTKDM4E | |
| SCHEMBL4962675 | 0.74 | THRA (0.53) | THRATHRBMAPTHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1297833-B1 | Indole carboxylic acids as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-12-21 | — | — | EP | claimed |