Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 4/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | RHEB | Q15382 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1642376 | 0.84 | THRA (0.64) | THRATHRBRHEB | |
| SCHEMBL6273659 | 0.83 | THRA (0.43) | THRATHRBRHEB | |
| SCHEMBL6275373 | 0.83 | THRA (0.36) | THRATHRBRHEB | |
| SCHEMBL6275042 | 0.79 | THRA (0.74) | THRATHRB | |
| SCHEMBL6269602 | 0.74 | THRB (0.52) | THRATHRB | |
| SCHEMBL6271809 | 0.72 | THRB (0.54) | THRATHRB | |
| SCHEMBL6274795 | 0.72 | THRB (0.45) | THRATHRBPTGS1PTGS2 | |
| SCHEMBL6273242 | 0.71 | THRB (0.49) | THRATHRB | |
| SCHEMBL6274146 | 0.71 | THRB (0.51) | THRATHRB | |
| SCHEMBL1641310 | 0.67 | THRA (0.57) | THRATHRBRHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1297833-B1 | Indole carboxylic acids as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-12-21 | — | — | EP | claimed |