Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 9/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628244 | 0.78 | MAPK1 (0.36) | FYNPDE10ACDK2MAPK1 | |
| SCHEMBL627384 | 0.77 | FYN (0.48) | NPY5RFYNPDE10AHASPIN | |
| SCHEMBL627537 | 0.76 | FYN (0.37) | NPY5RFYNPDE10AHASPIN | |
| SCHEMBL627536 | 0.76 | FYN (0.37) | NPY5RFYNPDE10AHASPIN | |
| SCHEMBL625118 | 0.75 | POLB (0.31) | MAPTMAPK1 | |
| SCHEMBL2255671 | 0.64 | ALDH1A1 (0.41) | FYNADORA2AADORA1MAPTALDH1A1 | |
| SCHEMBL1946929 | 0.64 | TP53 (0.51) | FYNMAPTKDM4EMEN1NPC1 | |
| SCHEMBL1944906 | 0.64 | FYN (0.47) | FYNMAPTKDM4EMEN1NPC1 | |
| SCHEMBL627055 | 0.64 | MAPT (0.48) | MAPTKDM4EMEN1LMNAKMT2A | |
| SCHEMBL1944534 | 0.63 | FYN (0.44) | FYNMAPTKDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |